Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

sod-3 (P41977) - Overview - Molecular Target Synopsis

Protein


sod-3, Superoxide dismutase [Mn] 2, mitochondrial
Enzyme Classification 1.15.1.1
UniProt P41977

Also Known as SODM2_CAEEL, sod-3

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Homotetramer.

6ELK
C.ELEGANS MNSOD-3 MUTANT - Q142H
RCSB/PDB
Inspect Structure
See all 3D Structures for sod-3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
218P41977-1

Sub-cellular localization


UniProt: sod-3 is active in the following subcellular-locations: mitochondrion.
GO terms: sod-3 is active in the following subcellular-locations: mitochondrial respirasome, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project sod-3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For sod-3 there are:
4 structures (8 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


sod-3 has been screened with compounds ( bioactivities). (see details)