Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

YRB1 (P41920) - Overview - Molecular Target Synopsis

Protein


YRB1, Ran-specific GTPase-activating protein 1
UniProt P41920

Also Known as YRB1_YEAST, YRB1, CST20, HTN1, SFO1

Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2. Interacts with GSP1 and PRP20.

6A38
MVM NS2 NES IN COMPLEX WITH CRM1-RAN-RANBP1
RCSB/PDB
Inspect Structure
See all 3D Structures for YRB1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
201P41920-1

Sub-cellular localization


UniProt: YRB1 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: YRB1 is active in the following subcellular-locations: cytoplasm, nuclear pore, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project YRB1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For YRB1 there are:
43 structures (43 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis