TFG1, Transcription initiation factor IIF subunit alpha
Also Known as
T2FA_YEAST, TFG1, SSU71
TFIIF is a general transcription initiation factor that binds to RNA polymerase II. Its functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation. TFIIF is composed of three different subunits: TFG1/RAP74, TFG2/RAP30 and TAF14.