Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TFG1 (P41895) - Overview - Molecular Target Synopsis

Protein


TFG1, Transcription initiation factor IIF subunit alpha
UniProt P41895

Also Known as T2FA_YEAST, TFG1, SSU71

TFIIF is a general transcription initiation factor that binds to RNA polymerase II. Its functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation. TFIIF is composed of three different subunits: TFG1/RAP74, TFG2/RAP30 and TAF14.

6GYL
STRUCTURE OF A YEAST CLOSED COMPLEX WITH DISTORTED DNA (CORE CCDIST)
RCSB/PDB
Inspect Structure
See all 3D Structures for TFG1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
735P41895-1

Sub-cellular localization


UniProt: TFG1 is active in the following subcellular-locations: nucleus.
GO terms: TFG1 is active in the following subcellular-locations: transcription factor TFIIF complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TFG1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For TFG1 there are:
11 structures (11 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis