Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SEC27 (P41811) - Overview - Molecular Target Synopsis

Protein


SEC27, Coatomer subunit beta'
UniProt P41811

Also Known as COPB2_YEAST, SEC27

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with the ESCRT-0 subunit VPS27.

4J79
CRYSTAL STRUCTURE OF BETA'-COP/PEDVSPIKE COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for SEC27

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
889P41811-1

Sub-cellular localization


UniProt: SEC27 is active in the following subcellular-locations: copi-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, golgi apparatus membrane.
GO terms: SEC27 is active in the following subcellular-locations: COPI vesicle coat, Golgi membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SEC27 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For SEC27 there are:
11 structures (17 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SEC27 has been screened with compounds ( bioactivities). (see details)