Molecular Target Synopsis
Overview
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Chemistry
Ligand Efficiency Plot
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NAA10 (P41227) - Overview - Molecular Target Synopsis

Protein


NAA10, N-alpha-acetyltransferase 10
Enzyme Classification 2.3.1.255
UniProt P41227

Also Known as NAA10_HUMAN, NAA10, ARD1, ARD1A, TE2

Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA15 or NAA16 (PubMed:20154145). Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, an down-regulates it when induced by hypoxia (PubMed:12464182). Interacts with NAA50 and with the ribosome (PubMed:16507339). Binds to MYLK (PubMed:19826488). Associates with HYPK when in complex with NAA15 (PubMed:15496142). Interacts with NAA15 (PubMed:15496142). Interacts with NAA16 (PubMed:19480662). Interacts (via its C-terminal domain) with TSC2, leading to its acetylation (PubMed:20145209). Interacts with NAA16 (PubMed:19480662). Interacts with IKBKB (PubMed:19716809). Interacts with HSPA1A and HSPA1B leading to its acetylation (PubMed:27708256).

6C95
THE HUMAN NATA (NAA10/NAA15) AMINO-TERMINAL ACETYLTRANSFERASE COMPLEX BOUND TO HYPK
RCSB/PDB
Inspect Structure
See all 3D Structures for NAA10

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NAA10 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: NAA10 is active in the following subcellular-locations: cytoplasm, cytosol, intracellular, membrane, NatA complex, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAA10 has gain in 2 cell-lines, loss in 18 cell-lines and no signal in 985 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SW 837, HEL, DMS 454

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, K562

(see details)

3D Structures


For NAA10 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis