PTGDS (P41222) - Overview - Molecular Target Synopsis
PTGDS, Prostaglandin-H2 D-isomerase
Enzyme Classification 22.214.171.124
Also Known as PTGDS_HUMAN, PTGDS, PDS
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Monomer.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|190||ENSG00000107317||ENST00000471521, ENST00000371625||ENSP00000435033, ENSP00000360687||P41222-1|
UniProt: PTGDS is active in the following subcellular-locations: cytoplasm, golgi apparatus, nucleus membrane, perinuclear region, rough endoplasmic reticulum, secreted.
GO terms: PTGDS is active in the following subcellular-locations: endoplasmic reticulum membrane, extracellular exosome, extracellular region, extracellular space, Golgi apparatus, nuclear membrane, perinuclear region of cytoplasm, rough endoplasmic reticulum.