Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PTGDS (P41222) - Overview - Molecular Target Synopsis

Protein


PTGDS, Prostaglandin-H2 D-isomerase
Enzyme Classification 5.3.99.2
UniProt P41222

Also Known as PTGDS_HUMAN, PTGDS, PDS

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Monomer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PTGDS is active in the following subcellular-locations: cytoplasm, golgi apparatus, nucleus membrane, perinuclear region, rough endoplasmic reticulum, secreted.
GO terms: PTGDS is active in the following subcellular-locations: endoplasmic reticulum membrane, extracellular exosome, extracellular region, extracellular space, Golgi apparatus, nuclear membrane, perinuclear region of cytoplasm, rough endoplasmic reticulum.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PTGDS has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, 786_0, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CL-11, OVKATE, KLE

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, NHLF

(see details)

3D Structures


For PTGDS there are:
16 structures (32 chains) solved
10 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PTGDS has been screened with compounds ( bioactivities). (see details)