Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RRN7 (P40992) - Overview - Molecular Target Synopsis

Protein


RRN7, RNA polymerase I-specific transcription initiation factor RRN7
UniProt P40992

Also Known as RRN7_YEAST, RRN7

Component of RNA polymerase I core factor complex (CF) that acts as a SUA7/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a pre-initiation complex. Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN7 interacts with RRN6, RRN11, SPT15 and RRN9.

5O7X
CRYSTAL STRUCTURE OF S. CEREVISIAE CORE FACTOR AT 3.2A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for RRN7

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
514P40992-1

Sub-cellular localization


UniProt: RRN7 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: RRN7 is active in the following subcellular-locations: nucleolus, RNA polymerase I core factor complex, RNA polymerase transcription factor SL1 complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RRN7 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RRN7 there are:
10 structures (15 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis