Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL4A (P40617) - Overview - Molecular Target Synopsis

Protein


ARL4A, ADP-ribosylation factor-like protein 4A
UniProt P40617

Also Known as ARL4A_HUMAN, ARL4A, ARL4

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARL4A is active in the following subcellular-locations: cell membrane, cytoplasm, nucleolus, nucleus.
GO terms: ARL4A is active in the following subcellular-locations: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL4A has gain in 16 cell-lines, loss in 2 cell-lines and no signal in 987 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: U251, K_562, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1581, C-33 A, SNU-484

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HMEC, HUVEC

(see details)

3D Structures


At greater than 35% identity similarity to ARL4A there are:
96 structures (194 chains) solved
85 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL4A has been screened with compounds ( bioactivities). (see details)