Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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FIS1 (P40515) - Overview - Molecular Target Synopsis

Protein


FIS1, Mitochondrial fission 1 protein
UniProt P40515

Also Known as FIS1_YEAST, FIS1, MDV2

Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation. Required for targeting MDV1 to the mitochondria. Regulates the assembly of DNM1 into punctate structures, in the mitochondrial tubules, promoting mitochondrial membrane constriction and/or division. Interacts with DNM1 and MDV1.

3UUX
CRYSTAL STRUCTURE OF YEAST FIS1 IN COMPLEX WITH MDV1 FRAGMENT CONTAINING N-TERMINAL EXTENSION AND COILED COIL DOMAINS
RCSB/PDB
Inspect Structure
See all 3D Structures for FIS1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
155P40515-1

Sub-cellular localization


UniProt: FIS1 is active in the following subcellular-locations: mitochondrion outer membrane.
GO terms: FIS1 is active in the following subcellular-locations: integral component of mitochondrial outer membrane, integral component of peroxisomal membrane, mitochondrial outer membrane, mitochondrion, peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FIS1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For FIS1 there are:
5 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis