Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLM1 (P40485) - Overview - Molecular Target Synopsis

Protein


SLM1, Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1
UniProt P40485

Also Known as SLM1_YEAST, SLM1, LIT2

Together with SLM2, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis. Heterodimer of SLM1-SLM2. Binds phosphatidylinositol 4,5-bisphosphate, which is required for function. Interacts with the TORC2 subunits AVO2, BIT61 and TOR2. Interacts with the calcineurin catalytic subunits CNA1 and CNA2.

4A6F
CRYSTAL STRUCTURE OF SLM1-PH DOMAIN IN COMPLEX WITH PHOSPHOSERINE
RCSB/PDB
Inspect Structure
See all 3D Structures for SLM1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
686P40485-1

Sub-cellular localization


UniProt: SLM1 is active in the following subcellular-locations: cell membrane.
GO terms: SLM1 is active in the following subcellular-locations: cytoplasm, mitochondrion, plasma membrane, TORC2 complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLM1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For SLM1 there are:
5 structures (16 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis