Molecular Target Synopsis
Overview
Domains and Structures
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Chemistry
Ligand Efficiency Plot
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RPC10 (P40422) - Overview - Molecular Target Synopsis

Protein


RPC10, DNA-directed RNA polymerases I, II, and III subunit RPABC4
UniProt P40422

Also Known as RPAB4_YEAST, RPC10, RPB12

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, the core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts, via its C-terminus, with TFIIIC subunit TFC4.

6O6C
RNA POLYMERASE II ELONGATION COMPLEX ARRESTED AT A CPD LESION
RCSB/PDB
Inspect Structure
See all 3D Structures for RPC10

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
70P40422-1

Sub-cellular localization


UniProt: RPC10 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: RPC10 is active in the following subcellular-locations: cytoplasm, nucleolus, nucleoplasm, nucleus, RNA polymerase I complex, RNA polymerase II, RNA polymerase III complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPC10 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RPC10 there are:
175 structures (178 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis