Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRE6 (P40303) - Overview - Molecular Target Synopsis

Protein


PRE6, Proteasome subunit alpha type-4
Enzyme Classification 3.4.25.1
UniProt P40303

Also Known as PSA4_YEAST, PRE6

The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with CIC1.

6HV5
YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH 4
RCSB/PDB
Inspect Structure
See all 3D Structures for PRE6

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
254P40303-1

Sub-cellular localization


UniProt: PRE6 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: PRE6 is active in the following subcellular-locations: cytoplasm, mitochondrion, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus, proteasome core complex, proteasome core complex, proteasome storage granule.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRE6 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For PRE6 there are:
291 structures (573 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PRE6 has been screened with compounds ( bioactivities). (see details)