Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NNMT (P40261) - Overview - Molecular Target Synopsis

Protein


NNMT, Nicotinamide N-methyltransferase
Enzyme Classification 2.1.1.1
UniProt P40261

Also Known as NNMT_HUMAN, NNMT

Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Monomer.

6CHH
STRUCTURE OF HUMAN NNMT IN COMPLEX WITH BISUBSTRATE INHIBITOR MS2756
RCSB/PDB
Inspect Structure
See all 3D Structures for NNMT

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
264ENSG00000166741ENST00000299964, ENST00000535401ENSP00000299964, ENSP00000441434P40261-1
80ENSG00000166741ENST00000541754ENSP00000445680

Sub-cellular localization


UniProt: NNMT is active in the following subcellular-locations: cytoplasm.
GO terms: NNMT is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NNMT has gain in 1 cell-lines, loss in 9 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, SNB_75, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2030, HCC515, NCI-H226

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, BJ, HUVEC

(see details)

3D Structures


For NNMT there are:
5 structures (20 chains) solved
5 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

NNMT is solved in complex with the approved drug(s):

NCA/NIACINAMIDE (3ROD_A, 3ROD_B, 3ROD_C, 3ROD_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NNMT has been screened with 6 compounds (7 bioactivities). (see details)