Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MMP12 (P39900) - Overview - Molecular Target Synopsis

Protein


MMP12, Macrophage metalloelastase
Enzyme Classification 3.4.24.65
UniProt P39900

Also Known as MMP12_HUMAN, MMP12, HME

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

6EKN
CRYSTAL STRUCTURE OF MMP12 IN COMPLEX WITH INHIBITOR BE7.
RCSB/PDB
Inspect Structure
See all 3D Structures for MMP12

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
470P39900-1

Sub-cellular localization


UniProt: MMP12 is active in the following subcellular-locations: extracellular matrix, extracellular space, secreted.
GO terms: MMP12 is active in the following subcellular-locations: cytoplasm, extracellular matrix, extracellular region, extracellular space, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MMP12 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_295, RPMI_8226, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 680N, G140, NCI-H2172

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For MMP12 there are:
81 structures (130 chains) solved
68 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MMP12 has been screened with 771 compounds (950 bioactivities), 359 compounds have bioactivities that show binding affinity of <= 500nM (447 bioactivities). (see details)