Molecular Target Synopsis
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FEN1 (P39748) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed16
Chains with at least one site assessed as druggable using the strict criteria10
Chains with at least one site assessed as druggable using the relaxed criteria16


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1UL1_Z Flap endonuclease 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 70.9 55.4 Yes Yes
2 empty 2.17 66 41.7 No No
3 empty 2.01 77.4 22.7 No No
4 empty 2.11 61.4 26.7 No No
5 empty 2.18 62.2 15.3 No No
6 empty 2.63 63.4 11.7 No No
7 empty 2.21 61.6 18.6 No No
8 empty 2.38 70.5 9.2 No No
9 empty 1.81 66.3 9.4 No No
10 empty 1.73 71.8 10.5 No No
3Q8K_A Flap endonuclease 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 67.2 41.6 Yes Yes
2 empty 1.49 71.4 28.9 Yes No
3 empty 2.37 64.3 22.2 No No
4 empty 2.35 62.5 30.9 No No
5 empty 2.07 66.5 14.4 No No
6 empty 2.44 65.2 13 No No
7 empty 2.07 66.5 13.2 No No
8 empty 1.98 59.1 15 No No
9 empty 1.92 66.2 10.3 No No
10 empty 2.1 59.9 15.3 No No
5ZOE_A Flap endonuclease 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 69.5 47.5 Yes Yes
2 empty 2.21 62.1 21 No No
3 empty 2.35 60.3 16.8 No No
4 empty 2.16 68.4 23.2 No No
5 empty 2.36 59 19.7 No No
6 empty 2.25 66.1 14.6 No No
7 empty 2.44 51.3 21.4 No No
8 empty 2.19 60.7 13.4 No No
9 empty 2.17 59.8 13.5 No No
10 empty 2.4 74.2 10.5 No No
1UL1_X Flap endonuclease 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 64 57.2 Yes No
2 empty 2.37 65.9 33.8 No No
3 empty 2 62 18.5 No No
4 empty 2.47 64 16.8 No No
5 empty 2.59 65.3 19.5 No No
6 empty 1.85 67.8 15.6 No No
7 empty 1.7 60.3 15.5 No No
8 empty 2.4 63.1 11.2 No No
9 empty 2.06 55 10.6 No No
10 empty 2.14 46.1 8.7 No No
1UL1_Y Flap endonuclease 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 64.1 37.3 Yes No
2 empty 2.04 58.1 35.9 No No
3 empty 2.49 70.8 27.3 No No
4 empty 1.84 72.8 14.8 No No
5 empty 1.82 61.2 20.3 No No
6 empty 1.56 63.2 16 No No
7 empty 2.08 60.3 14.5 No No
8 empty 2.28 68.1 15.1 No No
9 empty 1.83 59.3 14.1 No No
10 empty 1.82 81.2 12 No No
3Q8L_A Flap endonuclease 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 72.9 44 Yes Yes
2 empty 2.23 63.7 41.7 No No
3 empty 2.36 64.3 26 No No
4 empty 2.25 59.6 23.6 No No
5 empty 2.37 63.5 17 No No
6 empty 2.04 71.3 15.5 No No
7 empty 2.48 69 14.2 No No
8 empty 2.17 63.4 11.4 No No
9 empty 1.99 58.6 14.7 No No
10 empty 2.17 67.1 18.5 No No
5KSE_A Flap endonuclease 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 66.1 36.6 Yes Yes
2 empty 1.66 71 26.6 No No
3 empty 2.39 64.2 25.6 No No
4 empty 2.19 56 22.8 No No
5 empty 2.25 60.8 24.8 No No
6 empty 2.31 62.4 15.9 No No
7 empty 2.36 63 17.6 No No
8 empty 1.97 67.8 13.3 No No
9 empty 2.31 62.3 22.8 No No
10 empty 2.17 65 11.6 No No
5FV7_B Flap endonuclease 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 65.3 42.2 Yes No
2 empty 2.34 64.6 14.9 No No
3 empty 2.78 59.7 13.6 No No
4 empty 1.96 62.9 11.2 No No
5 empty 1.68 61.5 13.2 No No
6 empty 2.18 61.6 9.4 No No
7 empty 1.87 68.9 11.7 No No
8 empty 2.4 57.8 10 No No
9 empty 1.87 59.5 13.2 No No
10 empty 2.67 65.3 10.3 No No
5FV7_A Flap endonuclease 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 69.7 40.2 Yes Yes
2 empty 2.42 65.6 21.7 No No
3 empty 2.71 59.2 30.5 No No
4 empty 2.4 68.4 19.7 No No
5 empty 2.01 72.2 12.4 No No
6 empty 2.03 59.4 15.3 No No
7 empty 2.34 66 14.3 No No
8 empty 2.45 64 13.4 No No
9 empty 2.54 62.1 10.3 No No
10 empty 2.22 59.9 14.2 No No
5ZOD_A Flap endonuclease 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 65.2 24.8 Yes No
2 empty 2.12 65.5 29.1 No No
3 empty 2.34 62.1 17.3 No No
4 empty 2.09 61.3 19.8 No No
5 empty 2.16 65.2 25.8 No No
6 empty 2.19 65.3 18.7 No No
7 empty 2.38 61.6 11.9 No No
8 empty 2.56 64.3 14.5 No No
9 empty 2.71 68.6 12.8 No No
10 empty 2.27 55.7 15.4 No No
5K97_A Flap endonuclease 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 66.2 41 Yes Yes
2 empty 1.45 72.3 26.1 Yes No
3 empty 2.27 64.4 22 No No
4 empty 2.43 64.2 27 No No
5 empty 2.23 69 18.7 No No
6 empty 2.08 67.9 17.8 No No
7 empty 2.29 64.9 14.6 No No
8 empty 2.3 59.3 16.1 No No
9 empty 2.48 67.9 13.5 No No
10 empty 2.2 62.4 16.4 No No
5UM9_A Flap endonuclease 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 68.1 65.5 Yes Yes
2 empty 2.12 58.2 22.1 No No
3 empty 2.29 63.1 24.1 No No
4 empty 1.99 62 20.9 No No
5 empty 2.17 62.7 16 No No
6 empty 2.46 63.3 14 No No
7 empty 2.14 59.3 16.2 No No
8 empty 2.04 61.3 14.5 No No
9 empty 1.83 55.4 17.8 No No
10 empty 1.99 68.8 11.3 No No
3Q8M_A Flap endonuclease 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 67.4 63.6 Yes Yes
2 empty 2.28 77 18.4 No No
3 empty 2.26 65.5 21.3 No No
4 empty 2.16 66.5 15.2 No No
5 empty 2.31 66.4 11.2 No No
6 empty 2.3 75.5 11.4 No No
7 empty 2.04 60.5 13 No No
8 empty 1.77 61.8 14.7 No No
9 empty 2.61 69.7 14.2 No No
10 empty 2.59 67.2 11.5 No No
5ZOG_A Flap endonuclease 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 64.7 62.6 Yes No
2 empty 2.16 65.8 23.3 No No
3 empty 2.17 61.4 18.4 No No
4 empty 2.14 65.1 15.3 No No
5 empty 2.15 69.2 9.7 No No
6 empty 2.36 65.4 16 No No
7 empty 1.82 57.5 9.9 No No
8 empty 2.19 64 14.6 No No
9 empty 2.27 64.2 21 No No
10 empty 2.43 55.3 20.3 No No
5ZOF_A Flap endonuclease 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 63.5 29.1 Yes No
2 empty 1.66 72.5 21.3 Yes No
3 empty 2.36 62.2 25.5 No No
4 empty 2.16 63 14.5 No No
5 empty 2.21 62.3 26.4 No No
6 empty 2.71 68 22.7 No No
7 empty 2.1 70.9 17.4 No No
8 empty 2.3 64.6 11.8 No No
9 empty 2.27 64 14.8 No No
10 empty 2.33 58.8 11.2 No No
3Q8M_B Flap endonuclease 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 67.1 64.7 Yes Yes
2 empty 2.27 63.4 23.3 No No
3 empty 2.24 74.5 18.6 No No
4 empty 2.12 66.9 17 No No
5 empty 1.96 62 19.4 No No
6 empty 2.33 70.8 19.6 No No
7 empty 2.32 66.9 16.8 No No
8 empty 1.69 60.7 13.2 No No
9 empty 2.61 68.9 9.8 No No
10 empty 2.45 60.3 15.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed10
Domains assessed as druggable using the strict criteria5
Domains assessed as druggable using the relaxed criteria8

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1UL1_X (119690) Flap endonuclease 1 SAM domain-like, 5 to 3 exonuclease C-terminal subdomain, 5 to 3 exonuclease C-terminal subdomain 2.9Å No No
1UL1_X (119691) Flap endonuclease 1 PIN domain-like, PIN domain-like, 5 to 3 exonuclease catalytic domain 2.9Å Yes No
1UL1_Y (119692) Flap endonuclease 1 SAM domain-like, 5 to 3 exonuclease C-terminal subdomain, 5 to 3 exonuclease C-terminal subdomain 2.9Å No No
1UL1_Y (119693) Flap endonuclease 1 PIN domain-like, PIN domain-like, 5 to 3 exonuclease catalytic domain 2.9Å Yes No
1UL1_Z (119694) Flap endonuclease 1 SAM domain-like, 5 to 3 exonuclease C-terminal subdomain, 5 to 3 exonuclease C-terminal subdomain 2.9Å Yes No
1UL1_Z (119695) Flap endonuclease 1 PIN domain-like, PIN domain-like, 5 to 3 exonuclease catalytic domain 2.9Å Yes Yes
3Q8K_A (4168567) Flap endonuclease 1 PIN domain-like, PIN domain-like, 5 to 3 exonuclease catalytic domain 2.2Å Yes Yes
3Q8L_A (4095648) Flap endonuclease 1 PIN domain-like, PIN domain-like, 5 to 3 exonuclease catalytic domain 2.319Å Yes Yes
3Q8M_A (4134062) Flap endonuclease 1 PIN domain-like, PIN domain-like, 5 to 3 exonuclease catalytic domain 2.6Å Yes Yes
3Q8M_B (4258573) Flap endonuclease 1 PIN domain-like, PIN domain-like, 5 to 3 exonuclease catalytic domain 2.6Å Yes Yes
Ligand-based Druggability Score: 1.6
Ligand-based Druggability Score Percentile: 95%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


FEN1 is involved in 21 interactions in the network.


Druggability
Overall Druggability Percentile: 47.12
Druggability for Cancer Therapeutics: 84.80
Druggability for Other Therapeutics: 24.02
Cancer-Associated
Cancer-associated percentile : 88.15
Network Articulation Point
Is FEN1 critical for communication in the network?


Detailed Graph Legend:Help