Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

degQ (P39099) - Overview - Molecular Target Synopsis

Protein


degQ, Periplasmic pH-dependent serine endoprotease DegQ
Enzyme Classification 3.4.21.107
UniProt P39099

Also Known as DEGQ_ECOLI, degQ, hhoA

DegQ could degrade transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. DegQ is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for a beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable to be cleaved, thereby preventing non-specific proteolysis of folded proteins. DegQ can substitute for the periplasmic protease DegP. DegQ can reversibly switch between different oligomeric forms that represent inactive (6-mer) and active (12-and 24-mer) protease states. Substrate binding triggers the conversion of the resting DegQ trimer and hexamer into catalytically active 12- and 24-mers. The conversion of 6-mer (DegQ6) into 12-mer (DegQ12) or 24-mer (DegQ24) is crucial in regulating protease activity.

4A8B
SYMMETRIZED CRYO-EM RECONSTRUCTION OF E. COLI DEGQ 12-MER IN COMPLEX WITH LYSOZYMES
RCSB/PDB
Inspect Structure
See all 3D Structures for degQ

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
455P39099-1

Sub-cellular localization


UniProt: degQ is active in the following subcellular-locations: periplasm.
GO terms: degQ is active in the following subcellular-locations: integral component of external side of plasma membrane, periplasmic space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project degQ has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For degQ there are:
6 structures (72 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


degQ has been screened with compounds ( bioactivities). (see details)