Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

bmrR (P39075) - Overview - Molecular Target Synopsis

Protein


bmrR, Multidrug-efflux transporter 1 regulator
UniProt P39075

Also Known as BMRR_BACSU, bmrR, bmr1R

Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer. Binds DNA as a homodimer.

3Q5R
CRYSTAL STRUCTURE OF BMRR BOUND TO KANAMYCIN
RCSB/PDB
Inspect Structure
See all 3D Structures for bmrR

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
278P39075-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project bmrR has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For bmrR there are:
15 structures (15 chains) solved
12 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

bmrR is solved in complex with the approved drug(s):

KAN/KANAMYCIN (3Q5R_A),
ACH/ACETYLCHOLINE (3Q5S_A),
TAC/TETRACYCLINE (3Q5P_A).

(see details)
Molecular Target 3D Synopsis