Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

COL18A1 (P39060) - Overview - Molecular Target Synopsis

Protein


COL18A1, Collagen alpha-1(XVIII) chain
UniProt P39060

Also Known as COIA1_HUMAN, COL18A1

Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube., Non-collagenous domain 1: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling., Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295). May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123). Non-collagenous domain 1 forms homotrimers. Endostatin is monomeric (PubMed:11257123). Recombinant non-collagenous domain 1 has stronger affinity to NID1, HSPG2 and laminin-1:NID1 complex and lower affinity to FBLN1 and FBLN2 than endostatin. Endostatin interacts with KDR/VEGFR2. Endostatin interacts with the ITGA5:ITGB1 complex.

3HSH
CRYSTAL STRUCTURE OF HUMAN COLLAGEN XVIII TRIMERIZATION DOMAIN (TETRAGONAL CRYSTAL FORM)
RCSB/PDB
Inspect Structure
See all 3D Structures for COL18A1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: COL18A1 is active in the following subcellular-locations: basement membrane, extracellular matrix, extracellular space, secreted.
GO terms: COL18A1 is active in the following subcellular-locations: basement membrane, collagen trimer, collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix, extracellular region, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project COL18A1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, IGROV1, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H28, PANC-1, PA-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HUVEC, A549

(see details)

3D Structures


For COL18A1 there are:
3 structures (11 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis