Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

COL15A1 (P39059) - Overview - Molecular Target Synopsis

Protein


COL15A1, Collagen alpha-1(XV) chain
UniProt P39059

Also Known as COFA1_HUMAN, COL15A1

Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle., Restin potently inhibits angiogenesis. Trimer; disulfide-linked.

3N3F
CRYSTAL STRUCTURE OF THE HUMAN COLLAGEN XV TRIMERIZATION DOMAIN: A POTENT TRIMERIZING UNIT COMMON TO MULTIPLEXIN COLLAGENS
RCSB/PDB
Inspect Structure
See all 3D Structures for COL15A1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1388ENSG00000204291ENST00000375001ENSP00000364140P39059-1

Sub-cellular localization


UniProt: COL15A1 is active in the following subcellular-locations: extracellular matrix, extracellular space, secreted.
GO terms: COL15A1 is active in the following subcellular-locations: collagen type XV trimer, collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix, extracellular region, extracellular space, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project COL15A1 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: BT_549, SF_539, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 695T, G96, BT-549

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, NHLF, hMSC-AT

(see details)

3D Structures


For COL15A1 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis