Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STT3 (P39007) - Overview - Molecular Target Synopsis

Protein


STT3, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
Enzyme Classification 2.4.99.18
UniProt P39007

Also Known as STT3_YEAST, STT3

Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:12359722). This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (PubMed:29301962). Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:10677492, PubMed:16297388, PubMed:16096345, PubMed:15831493, PubMed:15886282, PubMed:9405463, PubMed:9435788, PubMed:29301962). OST assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains OST1 and OST5, subcomplex 2 contains STT3, OST3, and OST4, and subcomplex 3 contains OST2, WBP1, and SWP1 (PubMed:29301962). Interacts with SEC61 (PubMed:15831493).

6C26
THE CRYO-EM STRUCTURE OF A EUKARYOTIC OLIGOSACCHARYL TRANSFERASE COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for STT3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
718P39007-1

Sub-cellular localization


UniProt: STT3 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: STT3 is active in the following subcellular-locations: endoplasmic reticulum, integral component of membrane, oligosaccharyltransferase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STT3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For STT3 there are:
3 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis