Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IGHMBP2 (P38935) - Overview - Molecular Target Synopsis

Protein


IGHMBP2, DNA-binding protein SMUBP-2
Enzyme Classification 3.6.4.12
UniProt P38935

Also Known as SMBP2_HUMAN, IGHMBP2, SMBP2, SMUBP2

5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV. Homooligomer. Interacts with RUVBL1, RUVBL2, GTF3C1 and ABT1. Is part of large cytosolic ribonucleoprotein complexes (Probable). Associates with the ribosomes.

2LRR
SOLUTION STRUCTURE OF THE R3H DOMAIN FROM HUMAN SMUBP-2 IN COMPLEX WITH 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE
RCSB/PDB
Inspect Structure
See all 3D Structures for IGHMBP2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: IGHMBP2 is active in the following subcellular-locations: axon, cell projection, cytoplasm, nucleus.
GO terms: IGHMBP2 is active in the following subcellular-locations: axon, cytoplasm, growth cone, membrane, nucleus, ribonucleoprotein complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IGHMBP2 has gain in 22 cell-lines, loss in 0 cell-lines and no signal in 983 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, OVCAR_8, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: JHH-7, HCC515, EPLC-272H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)

3D Structures


For IGHMBP2 there are:
4 structures (5 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis