Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RPB11 (P38902) - Overview - Molecular Target Synopsis

Protein


RPB11, DNA-directed RNA polymerase II subunit RPB11
UniProt P38902

Also Known as RPB11_YEAST, RPB11

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft. Seems to be involved transcript termination. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

6I84
STRUCTURE OF TRANSCRIBING RNA POLYMERASE II-NUCLEOSOME COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for RPB11

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
120P38902-1

Sub-cellular localization


UniProt: RPB11 is active in the following subcellular-locations: nucleus.
GO terms: RPB11 is active in the following subcellular-locations: RNA polymerase II.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPB11 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RPB11 there are:
133 structures (135 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis