Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

GND1 (P38720) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed1
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria1


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2P4Q_A 6-phosphogluconate dehydrogenase, decarboxylating 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.21 71.1 35.5 Yes Yes
2 bound 1.81 68.2 24.3 No No
3 empty 2.09 61.9 24.7 No No
4 empty 1.81 66.7 19.7 No No
5 empty 2.45 65.7 24.1 No No
6 empty 2.06 60.9 16.6 No No
7 empty 1.55 48.2 20.1 No No
8 empty 2.29 64.3 20.8 No No
9 empty 2.09 57.3 18.1 No No
10 empty 1.82 72.4 21.1 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2P4Q_A (3170445) 6-phosphogluconate dehydrogenase, decarboxylating 1 6-phosphogluconate dehydrogenase C-terminal domain-like, 6-phosphogluconate dehydrogenase C-terminal domain-like, Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain 2.37Å Yes Yes
2P4Q_A (3170444) 6-phosphogluconate dehydrogenase, decarboxylating 1 NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, UNMATCHED 2.37Å No Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score