Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GND1 (P38720) - Overview - Molecular Target Synopsis

Protein


GND1, 6-phosphogluconate dehydrogenase, decarboxylating 1
Enzyme Classification 1.1.1.44
UniProt P38720

Also Known as 6PGD1_YEAST, GND1

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Homodimer.

2P4Q
CRYSTAL STRUCTURE ANALYSIS OF GND1 IN SACCHAROMYCES CEREVISIAE
RCSB/PDB
Inspect Structure
See all 3D Structures for GND1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
489P38720-1

Sub-cellular localization


UniProt: GND1 is active in the following subcellular-locations: cytoplasm.
GO terms: GND1 is active in the following subcellular-locations: cytoplasm, cytosol, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GND1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For GND1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GND1 has been screened with compounds ( bioactivities). (see details)