Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LIPA (P38571) - Overview - Molecular Target Synopsis

Protein


LIPA, Lysosomal acid lipase/cholesteryl ester hydrolase
Enzyme Classification 3.1.1.13
UniProt P38571

Also Known as LICH_HUMAN, LIPA

Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LIPA is active in the following subcellular-locations: lysosome.
GO terms: LIPA is active in the following subcellular-locations: fibrillar center, intracellular membrane-bounded organelle, lysosomal lumen, lysosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LIPA has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: M14, HOP_92, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DEOC-1, MIA Paca-2, RPMI 2650

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, BJ

(see details)

3D Structures


At greater than 50% identity similarity to LIPA there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LIPA has been screened with 32 compounds (63 bioactivities), 8 compounds have bioactivities that show binding affinity of <= 500nM (8 bioactivities). (see details)