Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

LIPA (P38571) - Overview - Molecular Target Synopsis


LIPA, Lysosomal acid lipase/cholesteryl ester hydrolase
Enzyme Classification
UniProt P38571

Also Known as LICH_HUMAN, LIPA

Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: LIPA is active in the following subcellular-locations: lysosome.
GO terms: LIPA is active in the following subcellular-locations: fibrillar center, intracellular membrane-bounded organelle, lysosomal lumen, lysosome.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project LIPA has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: M14, HOP_92, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DEOC-1, MIA Paca-2, RPMI 2650

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, BJ

(see details)

3D Structures

At greater than 50% identity similarity to LIPA there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

LIPA has been screened with 32 compounds (63 bioactivities), 8 compounds have bioactivities that show binding affinity of <= 500nM (8 bioactivities). (see details)