Molecular Target Synopsis
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MED8 (P38304) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed8
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria8


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3RJ1_J Mediator of RNA polymerase II transcription subunit 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 55.3 33.1 Yes No
2 empty 1.67 64.2 21.5 No No
3 empty 2 50.1 15.3 No No
4 empty 1.91 48.9 9 No No
5 empty 2.25 43.5 8.8 No No
6 empty 1.81 59.2 9.8 No No
7 empty 1.2 66.7 10.7 No No
8 empty 1.34 58.5 6.6 No No
9 empty 1.39 50 6.9 No No
10 empty 1.31 14.5 8.6 No No
5SVA_N Mediator of RNA polymerase II transcription subunit 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 54.2 34 Yes No
2 empty 1.72 54.7 21.3 No No
3 empty 1.51 69.9 12.1 No No
4 empty 1.52 59.6 10.3 No No
5 empty 1.86 44.8 9.7 No No
6 empty 2.06 51 10.1 No No
7 empty 1.16 23.4 10.9 No No
8 empty 2.67 54.6 8.3 No No
9 empty 1.69 83.9 5.7 No No
10 empty 1.28 70.6 7.9 No No
3RJ1_Q Mediator of RNA polymerase II transcription subunit 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.54 57.4 26 Yes No
2 empty 1.72 54.3 25.5 No No
3 empty 1.6 64.1 19.7 No No
4 empty 1.98 52.2 14.4 No No
5 empty 1.91 50.8 8.7 No No
6 empty 2.15 47.4 8.8 No No
7 empty 1.81 63.1 7.5 No No
8 empty 1.25 65.9 8.8 No No
9 empty 1.36 61.4 7.6 No No
10 empty 1.79 58 6 No No
3RJ1_C Mediator of RNA polymerase II transcription subunit 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 57.8 26.3 Yes No
2 empty 1.71 54.6 25.1 No No
3 empty 1.63 66.8 13.8 No No
4 empty 2.02 52 14.4 No No
5 empty 1.87 47.9 9.8 No No
6 empty 2.34 48.1 9.1 No No
7 empty 1.78 60.3 9.9 No No
8 empty 1.17 65.7 12 No No
9 empty 1.4 50 6.7 No No
10 empty 1.35 64.1 6 No No
4GWP_C Mediator of RNA polymerase II transcription subunit 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 54.9 33.5 Yes No
2 empty 1.64 52.7 20.6 No No
3 empty 1.5 68.3 11.6 No No
4 empty 1.87 37.8 12.1 No No
5 empty 1.92 44.4 9.2 No No
6 empty 2.42 58.7 11.7 No No
7 empty 2.67 65.2 10.3 No No
8 empty 2.02 50.6 7.8 No No
9 empty 1.61 38.9 10.9 No No
10 empty 1.14 22.4 11.1 No No
4GWQ_C Mediator of RNA polymerase II transcription subunit 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 55 30.7 Yes No
2 empty 1.67 52.5 16.8 No No
3 empty 1.5 66.6 11.9 No No
4 empty 1.85 46.5 9.9 No No
5 empty 1.85 38.2 13.1 No No
6 empty 2.52 61.4 11.5 No No
7 empty 2.01 50.6 8 No No
8 empty 2.03 56.4 8.2 No No
9 empty 1.14 20.4 11.1 No No
10 empty 1.95 54.7 8.9 No No
3J1O_J Mediator of RNA polymerase II transcription subunit 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.6 56 33.1 Yes No
2 empty 1.56 62.3 17.2 No No
3 empty 1.99 49 14.1 No No
4 empty 2.19 49 8.6 No No
5 empty 1.93 50.6 9 No No
6 empty 1.79 52.9 9.4 No No
7 empty 1.15 67.2 8.5 No No
8 empty 1.46 59.3 7.5 No No
9 empty 1.37 13.8 9 No No
10 empty 1.24 69.1 4.9 No No
5OQM_b Mediator of RNA polymerase II transcription subunit 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 51.5 33.7 Yes No
2 empty 1.51 54.1 16.4 No No
3 empty 2.06 61 14.6 No No
4 empty 1.69 73.8 8.4 No No
5 empty 1.44 52.3 9.8 No No
6 empty 1.93 49.3 8.9 No No
7 empty .94 77 6.5 No No
8 empty 1.02 68.8 6.9 No No
9 empty 2.24 55.5 7.1 No No
10 empty .87 65.7 6.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed1
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3RJ1_C (3700091) Mediator of RNA polymerase II transcription subunit 8 UNMATCHED, UNMATCHED, UNMATCHED 3RJ1 4.3Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score