Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FFC (P37107) - Overview - Molecular Target Synopsis

Protein


FFC, Signal recognition particle 54 kDa protein, chloroplastic
UniProt P37107

Also Known as SR54C_ARATH, FFC, CPSRP54

Involved in cotranslational and post-translational sorting of thylakoid proteins. Binds GTP specifically. Activates the GTPase activity of CPFTSY when bound together. Required for light-harvesting chlorophyll a/b-binding protein (LHCP) integration into thylakoids. Component of the cpSRP complex, composed of a FFC/cpSRP54 monomer and a CAO/cpSRP43 dimer. Interacts (via C-terminus) with CAO/cpSRP43 and with CPFTSY. Interacts with the third transmembrane domain of LHCP. Interacts with the PSBA/D1 nascent chain, but only when it is attached to the 70S ribosome and if it is shorter than 189 amino acid residues.

5L3R
STRUCTURE OF THE GTPASE HETERODIMER OF CHLOROPLAST SRP54 AND FTSY FROM ARABIDOPSIS THALIANA
RCSB/PDB
Inspect Structure
See all 3D Structures for FFC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
564P37107-1

Sub-cellular localization


UniProt: FFC is active in the following subcellular-locations: chloroplast stroma, plastid.
GO terms: FFC is active in the following subcellular-locations: chloroplast, chloroplast stroma, protein-containing complex, signal recognition particle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FFC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For FFC there are:
3 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis