Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BMPR1A (P36894) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed21
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria19


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1ES7_B Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 64 33.7 Yes No
2 empty 2.25 60.9 27.1 No No
3 empty 2.17 72.3 9.9 No No
4 empty 2.16 64 10.2 No No
5 empty 3.08 60.9 6.9 No No
6 empty 3.1 47.8 7.9 No No
7 empty 2.96 67.9 5.7 No No
8 empty 2.58 54.5 8.4 No No
9 empty 2.7 65.4 4.7 No No
10 empty 2.61 67 6.1 No No
2QJA_C Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 68.1 34.3 Yes No
2 empty 2.38 55.9 16.5 No No
3 empty 2.27 53.1 10.5 No No
4 empty 2.83 57.1 13.4 No No
5 empty 2.32 77.5 8.5 No No
6 empty 2.97 66.1 11.3 No No
7 empty 2.14 65.5 6.7 No No
8 empty 1.68 65.4 9.8 No No
9 empty 3.02 58.6 12.6 No No
10 empty 2.84 49.7 8.4 No No
3QB4_B Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 62.6 36.4 Yes No
2 empty 2.45 60.6 29 No No
3 empty 2.07 63.3 10.5 No No
4 empty 2.69 52 9.9 No No
5 empty 2.53 67.3 10.6 No No
6 empty 2.09 55.6 8 No No
7 empty 2.23 57.6 6.6 No No
8 empty 2.99 38.5 7.1 No No
9 empty 2.74 42.3 8.5 No No
10 empty 2.11 53 7.8 No No
3QB4_D Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 59.7 31.5 Yes No
2 empty 2.14 68.6 35.8 No No
3 empty 2.21 70.9 13.7 No No
4 empty 2.46 65.1 6.8 No No
5 empty 2.85 54.4 7.5 No No
6 empty 2.5 61.9 7.8 No No
7 empty 2.8 52.3 8.2 No No
8 empty 2.38 67.3 5.3 No No
9 empty 1.99 67.6 5.7 No No
10 empty 2.32 50.6 6.6 No No
3NH7_A Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 60.4 26.3 Yes No
2 empty 2.5 61.2 23.4 No No
3 empty 2.07 65.5 15.4 No No
4 empty 2.24 59.3 16.9 No No
5 empty 2.02 63.4 16.6 No No
6 empty 2.97 52.5 10 No No
7 empty 1.17 61.2 7.3 No No
8 empty 2.02 53.3 9.3 No No
9 empty 2.3 76.8 7.1 No No
10 empty 2.76 75.2 6.6 No No
2GOO_E Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 58.5 30.3 Yes No
2 empty 2.24 65 34.5 No No
3 empty 2.06 69.3 14.5 No No
4 empty 2.52 66.2 11 No No
5 empty 2.62 46.3 7.6 No No
6 empty 2.75 74.7 0 No No
7 empty 3.06 76.1 7.1 No No
8 empty 2.93 66.7 5.2 No No
9 empty 1.48 53.4 6 No No
10 empty 3.37 63.9 4.5 No No
2QJB_C Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 66.8 37.7 Yes No
2 empty 2.28 66.5 12.5 No No
3 empty 2.58 63.1 17.2 No No
4 empty 2.31 53.7 12.8 No No
5 empty 2.67 45.7 8.5 No No
6 empty 2.59 47.3 8.1 No No
7 empty 2.89 64 9.3 No No
8 empty 1.78 54.5 8.7 No No
9 empty 2.4 54.9 6.8 No No
10 empty 3.06 59.1 8.2 No No
3NH7_D Bone morphogenetic protein receptor type-1A No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 60.7 23.8 No No
2 empty 2.54 59.1 23.2 No No
3 empty 2.07 63.7 15.4 No No
4 empty 2.31 66.9 15.4 No No
5 empty 2.27 56.6 18 No No
6 empty 2.95 60.7 9.7 No No
7 empty 2.62 51.1 8.4 No No
8 empty 2.77 69.9 7.5 No No
9 empty 2.13 54.2 9.5 No No
10 empty 2.76 62 9.7 No No
1REW_C Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 63.7 33.1 Yes No
2 empty 2.55 59.9 32.5 No No
3 empty 2.48 76.4 8.4 No No
4 empty 2.9 56 11.8 No No
5 empty 2.33 63.3 9 No No
6 empty 2.73 63.5 7 No No
7 empty 2.05 77.6 0 No No
8 empty 3.27 56.8 8.9 No No
9 empty 1.97 65 6.3 No No
10 empty 2.59 64.4 7.6 No No
3NH7_C Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 59.5 30.2 Yes No
2 empty 2.05 66.6 15.4 No No
3 empty 2.25 62.2 17 No No
4 empty 2.37 62.4 14.4 No No
5 empty 3.01 60.9 10.6 No No
6 empty 1.94 67.6 8.7 No No
7 empty 2.65 79.5 10.1 No No
8 empty 2.42 55.3 9.6 No No
9 empty 2.67 78.3 6.2 No No
10 empty 2.67 63.2 9.3 No No
2QJ9_C Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 62.7 35.1 Yes No
2 empty 2.17 64.8 16.3 No No
3 empty 2.48 62.7 13.7 No No
4 empty 2.47 72.6 9.1 No No
5 empty 2.98 55.5 11.4 No No
6 empty 2.83 53.5 6.9 No No
7 empty 2.67 60.8 7.8 No No
8 empty 3.01 72.9 0 No No
9 empty 2.36 60.6 5.7 No No
10 empty 2.45 65.6 5.4 No No
2QJA_D Bone morphogenetic protein receptor type-1A No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 65.9 22.5 No No
2 empty 2.29 63.9 26.2 No No
3 empty 2 61.8 18.5 No No
4 empty 2.36 58.3 19.3 No No
5 empty 2.33 69.4 11.1 No No
6 empty 2.75 61.2 9.7 No No
7 empty 2.76 52.5 9.9 No No
8 empty 2.37 65.9 8 No No
9 empty 2.84 66.9 6.9 No No
10 empty 2.51 58.4 8 No No
2GOO_B Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 64.5 36.9 Yes No
2 empty 2.14 60.2 32.6 No No
3 empty 2.61 51.9 11.2 No No
4 empty 2.23 66.3 7.4 No No
5 empty 2.75 53.6 7.1 No No
6 empty 2.63 60.9 7.6 No No
7 empty 2.1 72.4 7.4 No No
8 empty 2.2 51.9 6.3 No No
9 empty 3.07 70.8 6.4 No No
10 empty 2.92 66.2 5.7 No No
2H64_B Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 64.4 33.5 Yes No
2 empty 2.1 57.1 28.7 No No
3 empty 2.74 61.5 11.8 No No
4 empty 2.56 82.1 0 No No
5 empty 2.22 60.3 8.8 No No
6 empty 2.51 53.8 7.6 No No
7 empty 2.74 64.5 10.5 No No
8 empty 2.27 66.4 6.4 No No
9 empty 2.88 72 7.3 No No
10 empty 3.12 56.1 6.6 No No
1REW_D Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 60 34.7 Yes No
2 empty 2.09 60 27.9 No No
3 empty 2.62 60.5 13 No No
4 empty 2.28 72.6 11 No No
5 empty 2.5 54.8 10 No No
6 empty 2.31 59.1 6.6 No No
7 empty 2.24 60.8 12.1 No No
8 empty 2.94 45.6 7.6 No No
9 empty 2.84 47.9 8.1 No No
10 empty 3.02 67 5.3 No No
2QJB_D Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 60.6 37 Yes No
2 empty 2.39 61.2 37.8 No No
3 empty 2.34 66 15.8 No No
4 empty 2.21 61.2 9.6 No No
5 empty 2.63 52.4 8 No No
6 empty 2.6 48.5 6.4 No No
7 empty 2.55 51.9 9 No No
8 empty 1.65 44.9 6.7 No No
9 empty 2.78 68.9 4.8 No No
10 empty 2.77 47.9 6.1 No No
2K3G_A Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 62.2 28.8 Yes No
2 empty 2.06 61.9 23 No No
3 empty 2.33 58.8 15.9 No No
4 empty 2.2 53 12.5 No No
5 empty 1.88 53.8 14.6 No No
6 empty 2.08 69.9 11.1 No No
7 empty 2.3 58.9 16 No No
8 empty 2.32 50.4 10.9 No No
9 empty 1.78 53.5 11.6 No No
10 empty 3.11 63.8 6.9 No No
3NH7_B Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 60.2 25.7 Yes No
2 empty 2.08 66 15.7 No No
3 empty 2.49 57.7 19.3 No No
4 empty 2.31 67.5 14.6 No No
5 empty 2.28 59.2 13.4 No No
6 empty 2.9 56 10.4 No No
7 empty 1.69 51.6 12.4 No No
8 empty 2.57 77.1 9.9 No No
9 empty 1.96 63.8 6.2 No No
10 empty 2.36 57.2 8.7 No No
2H62_C Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 62.2 36.5 Yes No
2 empty 2.22 61.4 27.7 No No
3 empty 1.81 68.5 10.9 No No
4 empty 1.97 65.7 9.6 No No
5 empty 2.68 62 6.9 No No
6 empty 2.12 48.4 6.4 No No
7 empty 2.73 59.7 6.8 No No
8 empty 1.83 48.5 7.5 No No
9 empty 1.98 62.3 8.3 No No
10 empty 2.65 43.9 6.9 No No
1ES7_D Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 64.2 37.6 Yes No
2 empty 2.35 58.6 35.8 No No
3 empty 2.2 73.1 9.1 No No
4 empty 2.38 64.8 7 No No
5 empty 2.62 69 10.6 No No
6 empty 2.69 57.8 7.4 No No
7 empty 2.56 48.3 9 No No
8 empty 3.15 60 5.8 No No
9 empty 2.92 65 5.7 No No
10 empty 2.1 50 5.8 No No
2QJ9_D Bone morphogenetic protein receptor type-1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 59.2 33.4 Yes No
2 empty 2.12 65 35.1 No No
3 empty 2.55 70.1 9.1 No No
4 empty 2.2 56 13.3 No No
5 empty 2.38 59.5 7.9 No No
6 empty 2.85 58.4 13.6 No No
7 empty 3.05 73.2 8.5 No No
8 empty 2.55 67.6 6.8 No No
9 empty 2.26 52.2 6.3 No No
10 empty 2.7 53.1 6.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed10
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria10

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1ES7_B (44465) Bone morphogenetic protein receptor type-1A Snake toxin-like, Snake toxin-like, Extracellular domain of cell surface receptors 2.9Å Yes No
1ES7_D (44466) Bone morphogenetic protein receptor type-1A Snake toxin-like, Snake toxin-like, Extracellular domain of cell surface receptors 2.9Å Yes No
1REW_C (97336) Bone morphogenetic protein receptor type-1A Snake toxin-like, Snake toxin-like, Extracellular domain of cell surface receptors 1.86Å Yes No
1REW_D (97337) Bone morphogenetic protein receptor type-1A Snake toxin-like, Snake toxin-like, Extracellular domain of cell surface receptors 1.86Å Yes No
2GOO_B (135442) Bone morphogenetic protein receptor type-1A Snake toxin-like, Snake toxin-like, Extracellular domain of cell surface receptors 2.15Å Yes No
2GOO_E (135445) Bone morphogenetic protein receptor type-1A Snake toxin-like, Snake toxin-like, Extracellular domain of cell surface receptors 2.15Å Yes No
2H62_C (136179) Bone morphogenetic protein receptor type-1A Snake toxin-like, Snake toxin-like, Extracellular domain of cell surface receptors 1.85Å Yes No
2H64_B (136181) Bone morphogenetic protein receptor type-1A Snake toxin-like, Snake toxin-like, Extracellular domain of cell surface receptors 1.78Å Yes No
2K3G_A (3140412) Bone morphogenetic protein receptor type-1A Snake toxin-like, Snake toxin-like, UNMATCHED Yes No
3NH7_A (3630986) Bone morphogenetic protein receptor type-1A Snake toxin-like, Snake toxin-like, UNMATCHED 2.7Å Yes No
Ligand-based Druggability Score: -1.05
Ligand-based Druggability Score Percentile: 68%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


BMPR1A is involved in 24 interactions in the network.


Druggability
Overall Druggability Percentile: 54.70
Druggability for Cancer Therapeutics: 71.97
Druggability for Other Therapeutics: 68.91
Cancer-Associated
Cancer-associated percentile : 90.22
Network Articulation Point
Is BMPR1A critical for communication in the network?


Detailed Graph Legend:Help