Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BMPR1A (P36894) - Overview - Molecular Target Synopsis

Protein


BMPR1A, Bone morphogenetic protein receptor type-1A
Enzyme Classification 2.7.11.30
UniProt P36894

Also Known as BMR1A_HUMAN, BMPR1A, ACVRLK3, ALK3

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. Interacts with BMP2 (PubMed:10881198, PubMed:18937504). Interacts with low affinity with GDF5; positively regulates chondrocyte differentiation (PubMed:24098149).

3QB4
CRYSTAL STRUCTURE OF A TGF-BETA LIGAND-RECEPTOR COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for BMPR1A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
532ENSG00000107779ENST00000372037ENSP00000361107P36894-1

Sub-cellular localization


UniProt: BMPR1A is active in the following subcellular-locations: cell membrane, cell surface.
GO terms: BMPR1A is active in the following subcellular-locations: dendrite, external side of plasma membrane, HFE-transferrin receptor complex, integral component of membrane, integral component of plasma membrane, neuronal cell body, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BMPR1A has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, T47D, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PA-1, SNU-484, A-673

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

RNA Interference


BMPR1A was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: A427, CAL51. (see details)

3D Structures


For BMPR1A there are:
11 structures (21 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


BMPR1A has been screened with 146 compounds (187 bioactivities), 14 compounds have bioactivities that show binding affinity of <= 500nM (14 bioactivities). (see details)