Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL2 (P36404) - Overview - Molecular Target Synopsis

Protein


ARL2, ADP-ribosylation factor-like protein 2
UniProt P36404

Also Known as ARL2_HUMAN, ARL2

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Found in a complex with ARL2, ARL2BP and SLC25A6. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Found in a complex with ARL2, ARL2BP and SLC25A4. The GTP-bound form interacts with PDE6D. Interacts with ELMOD2. The GTP-bound form interacts with ARL2BP. Interacts, preferentially in its GDP-bound state, with TBCD. Interacts with UNC119.

3DOF
COMPLEX OF ARL2 AND BART, CRYSTAL FORM 2
RCSB/PDB
Inspect Structure
See all 3D Structures for ARL2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
184ENSG00000213465ENST00000529384, ENST00000246747ENSP00000436021, ENSP00000246747P36404-1
157ENSG00000213465ENST00000533729ENSP00000432971P36404-2

Sub-cellular localization


UniProt: ARL2 is active in the following subcellular-locations: centrosome, cytoplasm, cytoskeleton, microtubule organizing center, mitochondrion intermembrane space, nucleus.
GO terms: ARL2 is active in the following subcellular-locations: centrosome, cytosol, focal adhesion, Golgi apparatus, lateral plasma membrane, mitochondrial intermembrane space, mitochondrial matrix, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL2 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_62, NCI_H522, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1581, MDST8, G96

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HUVEC, HeLa-S3

(see details)

3D Structures


For ARL2 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL2 has been screened with compounds ( bioactivities). (see details)