Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rplK (P36238) - Overview - Molecular Target Synopsis

Protein


rplK, 50S ribosomal protein L11
UniProt P36238

Also Known as RL11_THETH, rplK, rpl11

Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

3CJS
MINIMAL RECOGNITION COMPLEX BETWEEN PRMA AND RIBOSOMAL PROTEIN L11
RCSB/PDB
Inspect Structure
See all 3D Structures for rplK

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
147P36238-1, P62442-1, Q5SLP6-1

Sub-cellular localization


GO terms: rplK is active in the following subcellular-locations: ribosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rplK has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rplK there are:
9 structures (19 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis