Molecular Target Synopsis
Overview
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xyn2 (P36217) - Overview - Molecular Target Synopsis

Protein


xyn2, Endo-1,4-beta-xylanase 2
Enzyme Classification 3.2.1.8
UniProt P36217

Also Known as XYN2_HYPJR, xyn2

Glycoside hydrolase involved in the hydrolysis of xylan, a major plant cell wall hemicellulose made up of 1,4-beta-linked D-xylopyranose residues. Catalyzes the endohydrolysis of the main-chain 1,4-beta-glycosidic bonds connecting the xylose subunits yielding various xylooligosaccharides and xylose (PubMed:1369024, Ref.5). The catalysis proceeds by a double-displacement reaction mechanism with a putative covalent glycosyl-enzyme intermediate, with retention of the anomeric configuration (PubMed:7988708). Produces xylobiose and xylose as the main degradation products (PubMed:19556747).

5ZO0
NEUTRON STRUCTURE OF XYLANASE AT PD5.4
RCSB/PDB
Inspect Structure
See all 3D Structures for xyn2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
223P36217-1, G0RUP7-1

Sub-cellular localization


UniProt: xyn2 is active in the following subcellular-locations: secreted.
GO terms: xyn2 is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project xyn2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For xyn2 there are:
32 structures (40 chains) solved
23 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

xyn2 is solved in complex with the approved drug(s):

BEZ/BENZOIC ACID (1RED_B, 1REE_B, 1REF_B).

(see details)
Molecular Target 3D Synopsis