Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TFA2 (P36145) - Overview - Molecular Target Synopsis

Protein


TFA2, Transcription initiation factor IIE subunit beta
UniProt P36145

Also Known as T2EB_YEAST, TFA2

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). TFIIE is a tetramer of two alpha (TFA1) and two beta (TFA2) subunits.

6GYL
STRUCTURE OF A YEAST CLOSED COMPLEX WITH DISTORTED DNA (CORE CCDIST)
RCSB/PDB
Inspect Structure
See all 3D Structures for TFA2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
328P36145-1

Sub-cellular localization


UniProt: TFA2 is active in the following subcellular-locations: nucleus.
GO terms: TFA2 is active in the following subcellular-locations: transcription factor TFIIE complex, transcriptional preinitiation complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TFA2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For TFA2 there are:
8 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis