Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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CAF4 (P36130) - Overview - Molecular Target Synopsis

Protein


CAF4, CCR4-associated factor 4
UniProt P36130

Also Known as CAF4_YEAST, CAF4

Involved in mitochondrial fission. Has a partially redundant function to MDV1 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Plays a key role in determining the polarized localization of those DNM1 clusters that are not immediately involved in the mitochondrial fission process. Interacts with DNM1, FIS1 and MDV1, components of the mitochondrial fission machinery. Interacts via its WD repeats with DNM1. Interacts with CCR4 and NOT1, components of the CCR4-NOT complex. It is however not a component of the 1.0 MDa CCR4-NOT core complex, but appears to be part of a less characterized, 1.9 MDa CCR4-NOT complex. Interacts with DBF2, another likely component of the 1.9 MDa complex. Interacts with SRB9 and SRB10, components of the SRB8-11 complex.

2PQR
CRYSTAL STRUCTURE OF YEAST FIS1 COMPLEXED WITH A FRAGMENT OF YEAST CAF4
RCSB/PDB
Inspect Structure
See all 3D Structures for CAF4

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
643P36130-1

Sub-cellular localization


UniProt: CAF4 is active in the following subcellular-locations: mitochondrion outer membrane.
GO terms: CAF4 is active in the following subcellular-locations: CCR4-NOT complex, mitochondrial outer membrane, mitochondrion, PeBoW complex, preribosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CAF4 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For CAF4 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis