Molecular Target Synopsis
Overview
Domains and Structures
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Druggability
Chemistry
Ligand Efficiency Plot
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Gene Expression
Gene Copy Number Variation
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RPC37 (P36121) - Overview - Molecular Target Synopsis

Protein


RPC37, DNA-directed RNA polymerase III subunit RPC5
UniProt P36121

Also Known as RPC5_YEAST, RPC37

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with RPC53/RPC4. RPC53/RPC4, RPC37/RPC5 and RPC11/RPC10 probably form a Pol III subcomplex.

6CNF
YEAST RNA POLYMERASE III ELONGATION COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for RPC37

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
282P36121-1

Sub-cellular localization


UniProt: RPC37 is active in the following subcellular-locations: nucleus.
GO terms: RPC37 is active in the following subcellular-locations: RNA polymerase III complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPC37 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RPC37 there are:
15 structures (15 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis