Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RRN3 (P36070) - Overview - Molecular Target Synopsis

Protein


RRN3, RNA polymerase I-specific transcription initiation factor RRN3
UniProt P36070

Also Known as RRN3_YEAST, RRN3

Required for efficient transcription initiation by RNA polymerase I. Interacts with Pol I in the absence of template DNA and stimulates recruitment of Pol I, but does not remain as part of stable preinitiation complex. Monomer (Probable). Interacts with NOP53.

5OA1
RNA POLYMERASE I PRE-INITIATION COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for RRN3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
627P36070-1

Sub-cellular localization


UniProt: RRN3 is active in the following subcellular-locations: nucleus.
GO terms: RRN3 is active in the following subcellular-locations: nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RRN3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RRN3 there are:
7 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis