Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC16A2 (P36021) - Overview - Molecular Target Synopsis

Protein


SLC16A2, Monocarboxylate transporter 8
UniProt P36021

Also Known as MOT8_HUMAN, SLC16A2, MCT8, XPCT

Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr. Homodimer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC16A2 is active in the following subcellular-locations: cell membrane.
GO terms: SLC16A2 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC16A2 has gain in 0 cell-lines, loss in 26 cell-lines and no signal in 972 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: BT_549, SF_268, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-423, M059J, Hs 683

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, BJ, HMEC

(see details)


Screening and Chemistry


SLC16A2 has been screened with compounds ( bioactivities). (see details)