Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FUS (P35637) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed13
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6G99_B RNA-binding protein FUS No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 60.7 13.7 No No
2 empty 2.12 43.5 12.7 No No
3 empty 2.1 57.6 9.4 No No
4 empty 2.72 66.8 11.6 No No
5 empty 2.15 54.1 8 No No
6 empty 3.19 64.6 8.9 No No
2LCW_A RNA-binding protein FUS Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 62 27 Yes No
2 empty 2.61 55.6 16.4 No No
3 empty 2.8 60.3 13.6 No No
4 empty 2.28 64.2 9.1 No No
5 empty 2.12 61.1 11.1 No No
6 empty 1.98 65.9 8.2 No No
7 empty 3.41 47.6 10.2 No No
8 empty 2.65 62.4 8.6 No No
9 empty 1.85 55.6 12.3 No No
10 empty 2.17 49.6 7.3 No No
5W3N_C RNA-binding protein FUS No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.81 66.3 10.5 No No
2 empty 2.74 63.3 8.9 No No
3 empty 3.1 72 6.9 No No
4 empty 2.88 67.1 6.7 No No
5 empty 2.65 59.2 8.3 No No
6 empty 2.73 69.9 6.8 No No
7 empty 3.4 56.7 6.9 No No
8 empty 3.29 67.3 4.6 No No
9 empty 3.19 46.5 6.4 No No
10 empty 2.68 70.3 5.7 No No
2LA6_A RNA-binding protein FUS No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 49.4 19.9 No No
2 empty 2.1 65.7 13.1 No No
3 empty 1.79 61.6 10.7 No No
4 empty 2.07 60.8 10.5 No No
5 empty 2.29 56.6 14.7 No No
6 empty 2.54 46.1 10.2 No No
7 empty 2.14 59.3 8.1 No No
8 empty 2.06 53.5 10.9 No No
9 empty 2.88 63.2 7.1 No No
10 empty 2.24 65.8 6.4 No No
5W3N_G RNA-binding protein FUS No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.86 64.3 12 No No
2 empty 2.71 62.5 8.6 No No
3 empty 3.05 73.8 7.1 No No
4 empty 3.08 64.9 8.3 No No
5 empty 3.08 65.6 6.2 No No
6 empty 2.87 61.9 5.9 No No
7 empty 3.33 67.9 6.1 No No
8 empty 3.15 44.4 6.6 No No
9 empty 2.73 50 5.6 No No
10 empty 2.8 72.4 5.2 No No
5W3N_F RNA-binding protein FUS No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.71 64.2 11.5 No No
2 empty 3.08 70.9 7.1 No No
3 empty 3.07 71.3 0 No No
4 empty 2.74 61.1 7.1 No No
5 empty 2.79 69.8 7.4 No No
6 empty 3.32 58 6.7 No No
7 empty 2.81 50 8.2 No No
8 empty 2.98 45.5 6.7 No No
9 empty 3.26 70.4 5.5 No No
10 empty 2.64 76.9 4.9 No No
5W3N_A RNA-binding protein FUS No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.62 66.5 10.8 No No
2 empty 2.74 61.3 7.9 No No
3 empty 3.13 73.9 6.2 No No
4 empty 3 68.2 6.7 No No
5 empty 2.8 68.7 6.8 No No
6 empty 3.15 61.7 7 No No
7 empty 2.78 71.9 5.8 No No
8 empty 2.92 37.8 6.8 No No
9 empty 3.02 46.2 6.2 No No
10 empty 3.02 58.5 6.9 No No
5W3N_E RNA-binding protein FUS No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.74 63.2 11.5 No No
2 empty 2.74 62.4 9.5 No No
3 empty 2.9 66.7 7.9 No No
4 empty 3.18 76 7.1 No No
5 empty 2.63 55.8 8.2 No No
6 empty 2.81 64.5 6.1 No No
7 empty 3.36 61.9 6.4 No No
8 empty 3.24 70.1 6 No No
9 empty 2.56 71.1 5.5 No No
10 empty 2.8 40.5 8 No No
5W3N_B RNA-binding protein FUS No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.65 61.5 12.8 No No
2 empty 2.78 62.4 9.5 No No
3 empty 2.81 61.7 7.6 No No
4 empty 3.2 71 5.9 No No
5 empty 3.14 58.5 8.2 No No
6 empty 3.02 43.5 7 No No
7 empty 2.55 73.4 6.1 No No
8 empty 2.91 50 6.4 No No
9 empty 3.26 70 5.2 No No
10 empty 3.63 46.2 5.5 No No
5W3N_H RNA-binding protein FUS No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.72 60.7 11.6 No No
2 empty 2.74 64.9 7.8 No No
3 empty 2.82 62.5 10.2 No No
4 empty 3.18 71.8 6.6 No No
5 empty 2.89 71.1 0 No No
6 empty 3.2 48.4 6.2 No No
7 empty 2.85 44.9 5.5 No No
8 empty 3.19 62.9 5.8 No No
9 empty 2.7 76.1 4.7 No No
10 empty 2.98 63.4 4.8 No No
6GBM_B RNA-binding protein FUS Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.73 64.1 36.5 Yes No
2 empty 2.39 59.7 11.1 No No
3 empty 1.8 64.4 10.4 No No
4 empty 2.34 63.2 9.7 No No
5 empty 2.51 53.7 8.1 No No
6 empty 2.57 66.2 6.9 No No
7 empty 2.33 56.2 9 No No
8 empty 3.11 63.3 6.3 No No
9 empty 2.61 47.4 6.8 No No
10 empty 2.91 58.4 5.9 No No
5W3N_I RNA-binding protein FUS No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.86 65 9.7 No No
2 empty 2.71 64.4 8.4 No No
3 empty 3 72.8 6.8 No No
4 empty 3.2 61.2 8.5 No No
5 empty 2.74 69 6.9 No No
6 empty 3.33 61.2 6.5 No No
7 empty 3.07 45.7 6.4 No No
8 empty 2.7 48.1 6.7 No No
9 empty 3.3 70.9 5.4 No No
10 empty 3.53 50.6 5.6 No No
5W3N_D RNA-binding protein FUS No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.74 58 11.7 No No
2 empty 2.77 65.6 7.8 No No
3 empty 3.06 60.2 8.7 No No
4 empty 3.24 70.9 6.4 No No
5 empty 2.62 56.1 8.3 No No
6 empty 3.19 63.7 6.7 No No
7 empty 2.87 65.5 5.6 No No
8 empty 2.9 46.5 6.6 No No
9 empty 2.55 69.3 6.3 No No
10 empty 3.57 49.4 5.6 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


FUS is involved in 42 interactions in the network.


Druggability
Overall Druggability Percentile: 66.77
Druggability for Cancer Therapeutics: 85.46
Druggability for Other Therapeutics: 50.85
Cancer-Associated
Cancer-associated percentile : 97.62
Network Articulation Point
Is FUS critical for communication in the network?


Detailed Graph Legend:Help