Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TIE1 (P35590) - Overview - Molecular Target Synopsis

Protein


TIE1, Tyrosine-protein kinase receptor Tie-1
Enzyme Classification 2.7.10.1
UniProt P35590

Also Known as TIE1_HUMAN, TIE1, TIE

Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Heterodimer with TEK/TIE2.

5N06
CRYSTAL STRUCTURE OF TIE1 FIBRONECTIN-LIKE DOMAIN 3
RCSB/PDB
Inspect Structure
See all 3D Structures for TIE1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TIE1 is active in the following subcellular-locations: cell membrane.
GO terms: TIE1 is active in the following subcellular-locations: integral component of plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TIE1 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, LOXIMVI, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TYK-nu, TYK-nu.CP-r, HEL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, SK-N-SH, NHLF

(see details)

3D Structures


For TIE1 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TIE1 has been screened with 107 compounds (145 bioactivities), 17 compounds have bioactivities that show binding affinity of <= 500nM (26 bioactivities). (see details)