Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

HOXD12 (P35452) - Overview - Molecular Target Synopsis


HOXD12, Homeobox protein Hox-D12
UniProt P35452

Also Known as HXD12_HUMAN, HOXD12, HOX4H

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: HOXD12 is active in the following subcellular-locations: nucleus.
GO terms: HOXD12 is active in the following subcellular-locations: nucleus, transcription factor complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project HOXD12 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1581, Hs 746T, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 50% identity similarity to HOXD12 there are:
17 structures (29 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

HOXD12 has been screened with compounds ( bioactivities). (see details)