Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXD12 (P35452) - Overview - Molecular Target Synopsis

Protein


HOXD12, Homeobox protein Hox-D12
UniProt P35452

Also Known as HXD12_HUMAN, HOXD12, HOX4H

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
270ENSG00000170178ENST00000406506ENSP00000385586P35452-1
246ENSG00000170178ENST00000404162ENSP00000385132
217P35452-2

Sub-cellular localization


UniProt: HOXD12 is active in the following subcellular-locations: nucleus.
GO terms: HOXD12 is active in the following subcellular-locations: nucleus, transcription factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXD12 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1581, Hs 746T, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to HOXD12 there are:
17 structures (29 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXD12 has been screened with compounds ( bioactivities). (see details)