Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SPR (P35270) - Overview - Molecular Target Synopsis

Protein


SPR, Sepiapterin reductase
Enzyme Classification 1.1.1.153
UniProt P35270

Also Known as SPRE_HUMAN, SPR

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. Homodimer.

4Z3K
HUMAN SEPIAPTERIN REDUCTASE IN COMPLEX WITH THE COFACTOR NADP+ AND THE TRYPTHOPHAN METABOLITE XANTHURENIC ACID
RCSB/PDB
Inspect Structure
See all 3D Structures for SPR

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
261ENSG00000116096ENST00000234454ENSP00000234454P35270-1

Sub-cellular localization


UniProt: SPR is active in the following subcellular-locations: cytoplasm.
GO terms: SPR is active in the following subcellular-locations: cytosol, extracellular exosome, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SPR has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, A549, EKVX

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-719, DV-90, SK23

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HeLa-S3, HMEC

(see details)

3D Structures


For SPR there are:
6 structures (26 chains) solved
6 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

SPR is solved in complex with the approved drug(s):

YTZ/SULFATHIAZOLE (4J7U_A, 4J7U_B, 4J7U_C, 4J7U_D),
SAS/SULFASALAZINE (4J7X_A, 4J7X_B, 4J7X_F, 4J7X_J),
SFY/SULFAPYRIDINE (4HWK_A, 4HWK_B, 4HWK_C, 4HWK_D).

(see details)
Molecular Target 3D Synopsis