Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PTPN7 (P35236) - Overview - Molecular Target Synopsis

Protein


PTPN7, Tyrosine-protein phosphatase non-receptor type 7
Enzyme Classification 3.1.3.48
UniProt P35236

Also Known as PTN7_HUMAN, PTPN7

Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases.

3O4T
CRYSTAL STRUCTURE OF HEPTP WITH AN OPEN WPD LOOP AND PARTIALLY DEPLETED ACTIVE SITE
RCSB/PDB
Inspect Structure
See all 3D Structures for PTPN7

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PTPN7 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: PTPN7 is active in the following subcellular-locations: cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PTPN7 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, SR, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, KG-1, Jurkat, Clone E6-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, GM12878, CD34-positive mobilized cell

(see details)

3D Structures


For PTPN7 there are:
13 structures (13 chains) solved
3 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

PTPN7 is solved in complex with the approved drug(s):

TAR/TARTARIC ACID (3D42_A, 3O4T_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PTPN7 has been screened with 659 compounds (896 bioactivities), 45 compounds have bioactivities that show binding affinity of <= 500nM (56 bioactivities). (see details)