Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
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Ligand Efficiency Plot
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Interaction Network
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Germline Genetics

BMI1 (P35226) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed7
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria5


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3RPG_B Polycomb complex protein BMI-1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 58.2 22.5 No No
2 empty 1.65 59.2 24.3 No No
3 empty 1.83 49 18.2 No No
4 empty 2.28 61.9 22.4 No No
5 empty 2.2 68 13.5 No No
6 empty 1.99 61.6 8.5 No No
7 empty 2.27 66.2 9.4 No No
8 empty 1.74 54 10 No No
9 empty 2.63 58.7 8.9 No No
10 empty 3.13 61.5 5 No No
2CKL_A Polycomb complex protein BMI-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 58.1 25 Yes No
2 empty 1.72 63.8 24.2 No No
3 empty 2.32 64.8 19 No No
4 empty 1.96 55.5 15.2 No No
5 empty 2.18 61.1 17.4 No No
6 empty 2.43 56.2 13.1 No No
7 empty 1.9 59.1 8.8 No No
8 empty 1.25 65.3 8.9 No No
9 empty 2.76 61.5 6 No No
10 empty 2.39 57 9.3 No No
2H0D_A Polycomb complex protein BMI-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 58.3 26.6 Yes No
2 empty 1.58 68.1 22.3 No No
3 empty 1.87 47.3 19.4 No No
4 empty 2.43 64.4 21.6 No No
5 empty 2.21 61.5 12.3 No No
6 empty 2.33 56 11.7 No No
7 empty 1.83 61.1 10.1 No No
8 empty 2.53 56.4 7.3 No No
9 empty 1.84 64 9.1 No No
10 empty 3.28 61.1 6.7 No No
5FR6_A Polycomb complex protein BMI-1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 63.6 20.1 No No
2 empty 2.31 60.1 21.9 No No
3 empty 2.04 62.6 15.1 No No
4 empty 2.68 63 8.4 No No
5 empty 1.09 68.6 8.1 No No
6 empty 1.11 65.5 9.4 No No
7 empty 2.3 61.6 7.8 No No
8 empty 2.29 74.5 5.5 No No
9 empty 2.47 56.8 8.6 No No
10 empty 3.11 54.3 7.2 No No
2NA1_A Polycomb complex protein BMI-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 65.7 44.7 Yes No
2 empty 2.27 70.9 22.8 No No
3 empty 2.39 61.4 22.7 No No
4 empty 2 60.5 14.2 No No
5 empty 1.83 70.6 14.7 No No
6 empty 2.36 69.5 10.6 No No
7 empty 1.92 64.3 14.1 No No
8 empty 2.58 63.8 9.8 No No
9 empty 1.48 58.3 9.7 No No
10 empty 2.16 70.6 6.5 No No
4R8P_K Polycomb complex protein BMI-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 57.3 25.1 Yes No
2 empty 1.55 62.4 22.3 No No
3 empty 1.59 54.2 13.8 No No
4 empty 2.11 69.2 14.9 No No
5 empty 2 63.4 11 No No
6 empty 2.4 63.9 14.9 No No
7 empty 2.08 58.4 11 No No
8 empty 2.44 60.9 7.2 No No
9 empty 2.19 61.3 8.7 No No
10 empty 1.5 65.6 6.8 No No
4R8P_M Polycomb complex protein BMI-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 60 24.4 Yes No
2 empty 1.53 62 21.1 No No
3 empty 1.71 56.2 11 No No
4 empty 2.2 67.2 16.4 No No
5 empty 2.17 61.5 11.8 No No
6 empty 2.07 66.7 9.4 No No
7 empty 2.3 58.2 11.5 No No
8 empty 2.09 59.5 7.2 No No
9 empty 2.9 59.8 5.8 No No
10 empty 2.54 59.4 6.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed4
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2H0D_A (3100595) Polycomb complex protein BMI-1 PFAM, PFAM, PFAM zf-C3HC4 2.5Å No No
2H0D_A (3100596) Polycomb complex protein BMI-1 UNMATCHED, UNMATCHED, UNMATCHED 2H0D 2.5Å Yes No
3RPG_B (3700241) Polycomb complex protein BMI-1 PFAM, PFAM, PFAM zf-C3HC4 2.648Å No No
3RPG_B (3700242) Polycomb complex protein BMI-1 UNMATCHED, UNMATCHED, UNMATCHED 3RPG 2.648Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


BMI1 is involved in 38 interactions in the network.


Druggability
Overall Druggability Percentile: 68.68
Druggability for Cancer Therapeutics: 90.75
Druggability for Other Therapeutics: 44.52
Cancer-Associated
Cancer-associated percentile : 93.53
Network Articulation Point
Is BMI1 critical for communication in the network?


Detailed Graph Legend:Help