RYK (P34925) - Overview - Molecular Target Synopsis
RYK, Tyrosine-protein kinase RYK
Enzyme Classification 188.8.131.52
Also Known as RYK_HUMAN, RYK, JTK5A
May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. Interacts with DVL1 (via PDZ domain).
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UniProt: RYK is active in the following subcellular-locations: cytoplasm, membrane, nucleus.
GO terms: RYK is active in the following subcellular-locations: cytoplasm, integral component of membrane, integral component of plasma membrane, membrane, nucleus, plasma membrane, receptor complex.