Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RYK (P34925) - Overview - Molecular Target Synopsis

Protein


RYK, Tyrosine-protein kinase RYK
Enzyme Classification 2.7.10.1
UniProt P34925

Also Known as RYK_HUMAN, RYK, JTK5A

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. Interacts with DVL1 (via PDZ domain).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
607P34925-2
604P34925-1

Sub-cellular localization


UniProt: RYK is active in the following subcellular-locations: cytoplasm, membrane, nucleus.
GO terms: RYK is active in the following subcellular-locations: cytoplasm, integral component of membrane, integral component of plasma membrane, membrane, nucleus, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RYK has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, OVCAR_3, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NIH:OVCAR-3, HCC38, SNU-216

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to RYK there are:
149 structures (236 chains) solved
134 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

RYK is solved in complex with the approved drug(s):

LEV/LENVATINIB (5ZV2_A, 5ZV2_B),
0LI/PONATINIB (4V01_A, 4V01_B, 4V04_A, 4V04_B),
VGH/CRIZOTINIB (2WGJ_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RYK has been screened with compounds ( bioactivities). (see details)