Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EPHX2 (P34913) - Overview - Molecular Target Synopsis

Protein


EPHX2, Bifunctional epoxide hydrolase 2
Enzyme Classification 3.3.2.10
UniProt P34913

Also Known as HYES_HUMAN, EPHX2

Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510). Homodimer.

6I5G
X-RAY STRUCTURE OF HUMAN SOLUBLE EPOXIDE HYDROLASE C-TERMINAL DOMAIN (HSEH CTD)IN COMPLEX WITH 15D-PGJ2
RCSB/PDB
Inspect Structure
See all 3D Structures for EPHX2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: EPHX2 is active in the following subcellular-locations: cytoplasm, peroxisome.
GO terms: EPHX2 is active in the following subcellular-locations: cytosol, extracellular exosome, peroxisomal matrix, peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EPHX2 has gain in 0 cell-lines, loss in 10 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, T47D, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Jurkat, Clone E6-1, SW 1463, GP2d

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

3D Structures


For EPHX2 there are:
103 structures (112 chains) solved
100 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


EPHX2 has been screened with 1887 compounds (2592 bioactivities), 1305 compounds have bioactivities that show binding affinity of <= 500nM (1656 bioactivities). (see details)