Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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RPB7 (P34087) - Overview - Molecular Target Synopsis

Protein


RPB7, DNA-directed RNA polymerase II subunit RPB7
UniProt P34087

Also Known as RPB7_YEAST, RPB7

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex. The RPB4-RPB7 subcomplex probably associates with TFG1. Interacts with NRD1 and PAT1.

6I84
STRUCTURE OF TRANSCRIBING RNA POLYMERASE II-NUCLEOSOME COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for RPB7

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
171P34087-1

Sub-cellular localization


UniProt: RPB7 is active in the following subcellular-locations: cytoplasm, nucleus, p-body.
GO terms: RPB7 is active in the following subcellular-locations: cytoplasm, nucleus, P-body, RNA polymerase II.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPB7 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RPB7 there are:
74 structures (77 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis