Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GALNS (P34059) - Overview - Molecular Target Synopsis

Protein


GALNS, N-acetylgalactosamine-6-sulfatase
Enzyme Classification 3.1.6.4
UniProt P34059

Also Known as GALNS_HUMAN, GALNS

Homodimer.

4FDI
THE MOLECULAR BASIS OF MUCOPOLYSACCHARIDOSIS IV A
RCSB/PDB
Inspect Structure
See all 3D Structures for GALNS

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GALNS is active in the following subcellular-locations: lysosome.
GO terms: GALNS is active in the following subcellular-locations: azurophil granule lumen, extracellular exosome, extracellular region, lysosomal lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GALNS has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, SNB_75, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-398, NCI-H1581, NCI-H2452

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, IMR-90, NHLF

(see details)

3D Structures


For GALNS there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GALNS has been screened with compounds ( bioactivities). (see details)