Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TTK (P33981) - Overview - Molecular Target Synopsis

Protein


TTK, Dual specificity protein kinase TTK
Enzyme Classification 2.7.12.1
UniProt P33981

Also Known as TTK_HUMAN, TTK, MPS1, MPS1L1

Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. Interacts with TPR; the interactions occurs in a microtubule-independent manner.

6N6O
CRYSTAL STRUCTURE OF THE HUMAN TTK IN COMPLEX WITH AN INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for TTK

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: TTK is active in the following subcellular-locations: cytoplasm, kinetochore, membrane, nucleus, spindle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TTK has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: BT_549, CCRF_CEM, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVCAR-8, TK, Caov-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, HMEC, K562

(see details)

RNA Interference


TTK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SUM44, CAL120. (see details)

3D Structures


For TTK there are:
67 structures (75 chains) solved
61 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TTK has been screened with 1883 compounds (2553 bioactivities), 980 compounds have bioactivities that show binding affinity of <= 500nM (1095 bioactivities). (see details)