Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCC1 (P33527) - Overview - Molecular Target Synopsis

Protein


ABCC1, Multidrug resistance-associated protein 1
UniProt P33527

Also Known as MRP1_HUMAN, ABCC1, MRP, MRP1

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

4C3Z
NUCLEOTIDE-FREE CRYSTAL STRUCTURE OF NUCLEOTIDE-BINDING DOMAIN 1 FROM HUMAN MRP1 SUPPORTS A GENERAL-BASE CATALYSIS MECHANISM FOR ATP HYDROLYSIS.
RCSB/PDB
Inspect Structure
See all 3D Structures for ABCC1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCC1 is active in the following subcellular-locations: cell membrane.
GO terms: ABCC1 is active in the following subcellular-locations: basolateral plasma membrane, extracellular exosome, integral component of plasma membrane, membrane, plasma membrane, vacuolar membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCC1 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_5, A549, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PANC-1, G122, KYSE-70

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, A549

(see details)

3D Structures


For ABCC1 there are:
2 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCC1 has been screened with 1780 compounds (2301 bioactivities), 100 compounds have bioactivities that show binding affinity of <= 500nM (182 bioactivities). (see details)