Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CYP2C18 (P33260) - Overview - Molecular Target Synopsis

Protein


CYP2C18, Cytochrome P450 2C18
Enzyme Classification 1.14.14.1
UniProt P33260

Also Known as CP2CI_HUMAN, CYP2C18

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

2CIK
9 RESIDUE FRAGMENT OF
PEPTIDE
IN THE STRUCTURE OF
INSIGHTS INTO CROSSREACTIVITY IN HUMAN ALLORECOGNITION: THE STRUCTURE OF HLA-B35011 PRESENTING AN EPITOPE DERIVED FROM CYTOCHROME P450.
RCSB/PDB
Inspect Structure
See all 3D Structures for CYP2C18

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
490ENSG00000108242ENST00000285979ENSP00000285979P33260-1
431ENSG00000108242ENST00000339022ENSP00000341293P33260-2

Sub-cellular localization


UniProt: CYP2C18 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane.
GO terms: CYP2C18 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, organelle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CYP2C18 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, IGROV1, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: IM-95, MKN-45, IM-95m

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For CYP2C18 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CYP2C18 has been screened with 34 compounds (39 bioactivities). (see details)